LGBT characters

These are characters that are lesbian, gay, bisexual or transsexual.

Openly gay characters

 * Patty Bouvier - She almost married Veronica in "There's Something About Marrying".
 * John
 * Karl
 * Grady
 * Julio
 * The Sea Captain - bisexual
 * Roscoe

Hinted to be Gay

 * Waylon Smithers - Various scenes in the series hint he is gay and in love with Mr. Burns. Also once had a relationship with John.
 * Duffman - In Homerazzi, Bart mentions that he is supposedly in a long-term gay relationship after seeing him dining with Booberella. However, there are several different Duffmen.
 * Lenny Leonard - Sometimes hinted as being attracted to Carl.
 * Carl Carlson - Sometimes hinted as being attracted to Lenny.
 * Santa's Little Helper - Intrigued by male dogs at the Springfield Gay Pride Parade
 * Edna Krabappel - Hinted in Rome-Old and Julie-Eh that she may be in a relationship with Patty Bouvier.
 * Ralph Wiggum - In The Simpsons Movie, he declares "I like men now" after seeing Bart naked on a skateboard.

Transsexual

 * Judge Constance Harm indicates that she was born a man
 * Brunella Pommelhorst says she will return next semester as Mr. Pommelhorst, the new shop teacher.