Eliza Simpson

Eliza Van Houten (née Simpson) was an ancestor of Lisa Simpson (her great-great-great-great half aunt) who helped a man named Virgil get on the Underground Railroad. In a 1952 interview, there is a wedding photo in the background showing that Eliza ended up marrying Milford Van Houten, making Lisa Simpson and Milhouse Van Houten distantly related, as they are both descended from Mabel Simpson. She greatly resembles Lisa, but Lisa's hair is pointed.

There is also a character named Eliza Simpson in the episode Treehouse of Horror XV, though they are not the same character.