Cast and Crew

Regular Cast

 * Dan Castellaneta: Homer Simpson, Grampa Simpson, Mayor Quimby, Krusty the Clown, Sideshow Mel, many others.
 * Julie Kavner: Marge Simpson, Patty Bouvier, Selma Bouvier, Jacqueline Bouvier
 * Nancy Cartwright: Bart Simpson, Nelson Muntz, Todd Flanders, Ralph Wiggum, ^Maggie Simpson, many others.
 * Yeardley Smith: Lisa Simpson
 * Hank Azaria: Moe Szyslak, Clancy Wiggum, Apu Nahasapeemapetilon,Professor Frink, Comic Book Guy, many others.
 * Harry Shearer: Mr. Burns, Waylon Smithers, Principal Skinner, God, Reverend Timothy Lovejoy, many others.

^ Generally Nancy Cartwright voices Maggie Simpson's squeaks, giggles and burps. But other people have also voiced her in certain episodes: Elizabeth Taylor guest voiced as her in Lisa's First Word, Harry Shearer voiced her in a treehouse of horror episode using his Kang voice, and James Earl Jones voiced her in another treehouse of horror episode using his Darth Vader voice.

Recurring Cast

 * Tress MacNeille: Agnes Skinner, Dolph Starbeam, Crazy Cat Lady, Cookie Kwan, Brandine Spuckler, many others.
 * Pamela Hayden: Milhouse Van Houten, Rod Flanders, Jimbo Jones, Sarah Wiggum, Janey Powell, many others.
 * Maggie Roswell: Helen Lovejoy, Maude Flanders, Elizabeth Hoover, Luann Van Houten, Mary Bailey, many others.
 * Russi Taylor: Martin Prince
 * Karl Wiedergott: Additional Voices.

Recurring Guest Stars

 * Marcia Wallace: Edna Krabappel
 * Kelsey Grammer: Sideshow Bob
 * Albert Brooks: Cowboy Bob, Hank Scorpio, Jacques, Cowboy Bob, Tab Spangler
 * Jon Lovitz: Artie Ziff, Professor Lombardo, Aristotle Amadopolis, Jay Sherman, Llewellyn Sinclair
 * Joe Mantegna: Fat Tony
 * Jan Hooks: Manjula Nahasapeemapetilon
 * Jane Kaczmarek: Judge Constance Harm
 * Maurice LaMarche: Additional Voices.

Former Cast

 * Marcia Mitzman Gaven: A variety of Roswell's roles.
 * Doris Grau: Lunchlady Doris
 * Phil Hartman: Troy McClure, Lionel Hutz, Lyle Lanley, Noah, Moses, many others.
 * Jo Ann Harris: Martin Prince
 * Christopher Collins: Moe Szyslak, Mr. Burns
 * Frank Welker: Additional Voices.

Producers

 * Matt Groening
 * James L. Brooks
 * Sam Simon

Writers

 * David Cohen
 * Al Jean
 * Ian Maxtone-Graham
 * George Meyer
 * Bill Oakley
 * Conan O'Brien
 * Mike Reiss
 * John Swartzwelder
 * Jon Vitti
 * Josh Weinstein