Little Big Mom/References

Cultural References

 * The episode title is a pun on the film Little Big Man.
 * The Virtual Doctor website says that it's from the creators of Dragon Quest and SimSandwich. Dragon Quest is a series of RPGs released by Square-Enix (originally released as Dragon Warrior in the US). SimSandwich is a reference to the Sim series of games, the most famous of which is SimCity.
 * In the hospital, Homer and Bart squirt interferon at each other.
 * Homer and Bart watch an episode of "I Love Lucy."
 * At the very end of the episode, Homer sings "Aloha 'Oe" between screams while he receives a needle treatment.

Trivia

 * During the Itchy &amp; Scratchy cartoon, the pictures Itchy looks at in his photo album are from previous I&S cartoons (see "Tears of a Clone").
 * This is the first episode broadcast in the new millenium, 2000.

Goofs

 * The clock falls on Marge's left leg, yet it breaks her right leg.
 * Unless Bart and Homer were squeezing the bag, an IV line doesn't have enough pressure to squirt.
 * Bart and Homer seems to be fooled that they had leprosy despite Lisa using green poster paint instead of brown or red to make them really think it's leprosy.
 * Deers are plant-eaters and would've just run away from Lisa since they appear to be healthy.
 * How did Lisa and Marge get to Hawaii for free if Flanders had to pay to send Bart and Homer?