25 in total.
Marge Simpson: The main character of the show who once took antibirth pills as a young adult. No longer able to give birth, she had to adopt two kids, Bart and Lisa, because now she wants to be a mom. She works at the Springfield power plant and is Mr. Burns' favorite employee there.
Homer Simpson: Marge's fat "idiot sidekick" husband who is obsessed with eating donuts and drinking beer, even though it's not healthy for him. He's a stay-at-home dad who takes care of the two children that aren't even his, while his wife Marge is away doing her job at the power plant.
Bart Simpson (Formerly "Bart Lovejoy"): The older of Marge and Homer's two adopted children who was adopted by them after Mr. and Mrs. Lovejoy died. Used to be a good-mannered little boy back in the day, but Homer led him into a life as a troublemaker soon after he was adopted by him.
Lisa Simpson (Formerly "Lisa Lovejoy"): The younger of Marge and Homer's two adopted children who was adopted by them after Mr. and Mrs. Lovejoy died. Unlike her brother Bart, she is still the good-mannered little girl that Mr. and Mrs. Lovejoy loved so dearly, but not as religious anymore.
Ned Flanders: Homer and Marge's neighbor. Since Mr. Lovejoy died, he has taken over his duties as the reverend at the First Church of Springfield. He despises Bart and Lisa being with Homer and Marge after the Lovejoys' death, saying that the childrens' religious spirit is being sucked out.
Principal Seymour Skinner: The principal at the Elementary school in Springfield, which Bart and Lisa attend. Skinner, despite being 51, still lives with his 95-year-old mother Agnes. He just wishes that his mother would move to a nursing home, one far from Springfield, and let him live alone.
Moe Szyslak: The cranky bar owner who seems to be attempting to "poison" Homer, as he serves 5 glasses of beer to Homer a day. Marge despises Moe and wants him out of town. Despite attempts from the health inspector to close Moe's bar, he's still serving beer and bad advice.
Mr. Burns: The greedy owner of the power plant where Marge works, who doesn't care about most other people and spends his days counting money and only giving his employees, excluding top-tiers like Marge, a cent a day. He has a assistant, Mr. Smithers, who secretly wants to kill him.
Apu: The owner of the struggling store, the Kwik-E-Mart, which has failed to compete with the larger Sprawl-Mart nearby. He is a great friend to Homer and Marge, as they are some of the last customers he still has. He hasn't been seen much lately, and viewers assume he's gone bankrupt.
Chief Wiggum: The local cop in the Simpsons' neighborhood, who is very bad at his job and is only still on the Springfield Police team because he is following the tradition of cops eating donuts. Wiggum is in tears of seeing Bart vandalising, but is too scared of being fired for arresting Homer.
Milhouse Van Houten: A pink-shirted nerd who lives on the other side of Flanders' house and is friends with Bart and Lisa. He had wanted to be friends with Bart and Lisa ever since he was 4, except Mr. Lovejoy originally didn't let him because Milhouse was simply "not religious enough".
Grampa: Homer's father and Marge's father-in-law, who went crazy over finally having grandkids, albeit adopted ones, as he had long feared that Homer would die alone. This got him taken away, and he now lives at the insane asylum, but Homer and Marge prefer not to tell this to the kids.
Barney Gumble: The infamous town drunk who keeps burping in public like a complete fool, which angers the government. Barney is Homer's very best friend and is often seen at Moe's bar with him. Unfortunately, the mayor of Springfield wants Barney killed for constantly burping in public.
Mr. Smithers: Mr. Burns's long-suffering assistant who Burns forces to do all his dirty chores and can't believe that Mr. Burns values employees like Marge more than he values his own assitant. Because of his mishandeling, Smithers secretly wants to kill Mr. Burns and take over the plant.
Krusty the Clown: The famous clown who is beloved by all the children in Springfield despite the fact that he smokes pot. Bart and Lisa used to despise him when they lived with Mr. and Mrs. Lovejoy, but they eventually became his biggest fans after Homer gave them Krusty's autograph.
Otto Mann: The worst bus driver in Springfield. Otto uses drugs 24/7, which often makes him crash the school bus into the same damn pond and force the kids to walk to school every day. Unlike some other people in Springfield, he likes the new Bart and hated the old, religious Bart.
Groundskeeper Willie: A illegal Scottish immigrant who works at Bart and Lisa's school, where he cleans up after everyone's messes, and he also lives there because he's too poor to buy a actual house. Willie cannot speak normal English, he only brabbles, much to Principal Skinner's dismay.
Lenny and Carl: Marge's two coworkers at the power plant who often join Homer and Barney in getting drunk at Moe's bar, which causes them to be bad-tier employees in Mr. Burns's eyes. Marge is ashamed of them, and it's a miracle that Lenny and Carl still work at the power plant.
Nelson Muntz: Barney's nephew who bullies Bart and Lisa at school, as he thinks they're still religious. Nelson, despite being the youngest of the school bullies, is the leader of them, and therefore, the older bullies Jimbo, Dolph and Kearney have to listen to him like he's a dictaror.
Ralph Wiggum: Chief Wiggum's notoriously dumb son who can't even spell his own name right and keeps getting held back. This is evident by that Ralph is the same age as Bart, but is in Lisa's class at school. He also unknowingly tries to kill himself by eating paste for breakfast, lunch and dinner.
Sideshow Bob: Krusty's sidekick on his show who is always humiliated by getting shot out of a canon, but prefers it over his home life where he is married to a crazy cat lady. Because of him preferring his life on Krusty's show, Bob has been starting to get a rather toxic crush on the clown.
Comic Book Guy: A freak with cancer who runs the local comic book store, "The Android's Dungeon and Baseball Card Shop". He often scams people for their money by buying really rare stuff for really low prices, and is a jerk who refuses to sell any comic book issue with a "#1" on it.
Mayor Quimby: The rather awful mayor of Springfield and Barney's biggest enemy. Quimby has been elected mayor for 26 years straight despite his incompetence, because he always rigs the votes. He also has a quite embrassing secret where he uses his gavel to flatten steaks at home.
Patty and Selma Bouvier: Marge's sisters who, quite unhealthily, smoke at least three times a day and, more healthily, work at the Springfield DMV. Unfortunately, they talk trash to others for most of their work hours, which makes them the cause of the DMV's long wait lines, and also hated.
Maggie Bouvier: Selma's baby daughter and Homer and Marge's niece who's occasionally babysat by the Simpsons. Her cuteness is the reason why Marge suddenly wanted kids of her own despite her swallowing antibirth pills at 19. Bart and Lisa like to play with her whenever she comes over.
Note: Maggie Bouvier is this universe's version of the canon Maggie Simpson and the deceased Mr. and Mrs. Lovejoy are indeed Reverend Lovejoy and Helen Lovejoy.
