Here are my theories of what would happen if there is one specific character (mainly a girl) who is like a combination of Bart and Lisa:
She would be both smart and athletic, in other words, she will be good at both intellectual stuff and sports.
She will be morally correct while also rebellious as well.
Her hobbies would involve: pulling pranks, practicing the saxophone, play video games and solved puzzles.
She will also be an environmentalists who is a vegetarian and love animals and nature.
Her taste is music would be Hip-Hop, and Jazz music.
She will be caring about women empowerment.
Her idea toys will involve action figures and dolls.
She will be the biggest fan of superheroes.
She would also love itchy and scratchy.
She will like extreme sports (particularly skateboarding.
She will be interested in reading books too.
She might have the same (or rather similar) allergies and mental health conditions.
Her blood type will be O negative and she will have an IQ of 159.
She would even be a great graffiti artist as well, although she could probably be terrible at drawing.
Her favourite animal would definitely be horse.
She will be the type a person that love to learn.
She might have some problems making friends or became really popular in school.
She will be pretty skilful with the Saxophone.
She will dress like both Bart and Lisa.
She will even be adventurous and cunning.