Arby's is a fast food restaurant in the U.S., known for roast beef, turkey, and premium Angus meat sandwiches, as well as the Jamocha shake.
When the members of Springfield Elementary' Model U.N. Club stranded on an island in the middle of nowhere. There was no food on the island, so Sherri said that she is so hungry she could "eat at Arby's". It then caused other children to gasp.
When Santa's Little Helper became a new mascot of Duff Beer, he started appear in various beer commercials. In one, he was showed partying with some young women. During watching the ad, Lisa asked why a dog would have human girlfriends. Marge told her that people do crazy things in ads, "like eat at Arby's".
When Kirk Van Houten separated from his wife Luann and was living in an apartment, he proposed disposing of a dead opossum by throwing it over the fence into Arby's parking lot.
In "The Wreck of the Relationship" when Marge is reading trash talk directed at Homer's fantasy football team, one comment states "your RB is worse than Arby's," insulting both Homer's running back and the franchise.
An Arby's restaurant is seen in "Fatzcarraldo" as Homer is driving by, along with Tofu Bell and Kentucky Steamed Chickpeas. The building has resemblance to a real-life Arby's restaurant but it does not have the chain's cowboy hat sign.
When Homer was trying to eat the blob, he said that if he could "keep down Arby's", then he could "keep down" the blob.