Big "NO!" is a catchphrase that appears in these situations:
NOOOOOOOOOOOOOOO!!!!!!!!!!!!!!!!!!!!!!!!!
- Lisa's reaction to Ralph Wiggum humiliating her in "I Love Lisa".
- Homer's reaction to Burns' Arena in "The Simpsons Road Rage".
- Homer's reaction to Santa's Little Helper howling in "Bart's Dog Gets an F".
- Barney's reaction to his Rage in "The Simpsons Road Rage".
- Homer's reaction to Dondelinger burning a donut in "The Front".
- Principal Skinner's reaction to Bart's Big Butt Skinner balloon, discovering a comet, and finding out that school is for losers in "Bart's Comet".
- Bart's reaction to Marge Simpson in "Milhouse of Sand and Fog".
- The Grand Pumpkin's reaction to Homer Simpson making a jack-o'-lantern in "Treehouse of Horror XIX".
- Marge's reaction to young Bart when a bubble is floating away and popped in "A Mid-Childhood Night's Dream".
- Homer's reaction to Lisa is heading to the final race in "Lisa Gets an F1".
- Homer's reaction to Marge Simpson after Julio said that every food delivery app is shut down in "Night of the Living Wage".