Characters who often disagree with Homer and/or see him as a problem and/or characters that Homer hates.
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- Baby Gerald's Brother
- Babysitting Lady
- Bartie Ziff
- Beatrice (Dangerous Curves)
- Daphne Beaumont
- Betty White (character)
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- Bildorf
- Billy (flashback)
- Billy the Kid
- Blue Demon
- Blue-eyed husband
- Blue-Haired Lawyer
- Boba Fett
- Bobo (dog)
- Mr. Bont
- Boogeyman
- Scotty Boom
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- Clancy Bouvier
- Jacqueline Bouvier
- Patty Bouvier
- Selma Bouvier
- Hugs Bunny
- Burglar 1 (couch gag)
- Burglar 2 (couch gag)
- Charles Montgomery Burns
- George H. W. Bush
- George W. Bush
- Businessmen (Treehouse of Horror XXI)
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