A list of characters with various disabilities, illnesses, conditions, etc.
Physical & physiological[]
- Abe Simpson II - visual impairment, elderly age, limited mobility
- Agnes Skinner - elderly age, irritable bowel syndrome (IBS)
- Anton Lubchenko - amputee - left leg
- Bart Simpson - tracheal trauma
- Carl Carlson - diabetes
- Charles Montgomery Burns - elderly age, hair loss, radioactivity, radiation poisoning, sterility, limited mobility
- Clancy Bouvier - lung cancer
- Clancy Wiggum - formerly asthma
- Dia-Betty - diabetes
- Dubya Spuckler - visual impairment, vestigial tail
- Eddie - gout
- Gary Coleman - dwarfism
- Gravedigger Billy - walks with a limp
- Hans Moleman - visual impairment, limited mobility
- Herman Hermann - amputee - right arm
- Homer Simpson - hearing loss, hair loss, cranial trauma, radioactivity, sterility
- Horatio McCallister - visual impairment, amputee - leg
- Jasper Beardsley - visual impairment, elderly age, diabetes, limited mobility, amputee - left leg
- Jitney Spuckler - scoliosis
- Joe C. - dwarfism, celiac disease
- Krusty the Clown - heart disease requiring use of pacemaker
- Legs - possible visual impairment
- Lenny Leonard - radioactivity, eye trauma
- Ling Bouvier - diabetes
- Lisa Simpson - hay fever, formerly dental corrections
- Maya - dwarfism
- Melvin Van Horne - lactose intolerance
- Milhouse Van Houten - lactose intolerance, allergies, asthma
- Mona Simpson - elderly age, limited mobility
- Monk Murphy - congenital deafness
- Most Springfield residents - obesity
- Ned Flanders - possible visual impairment, scarring, syncope
- Normal Head Joe Spuckler - hydrocephalus
- Ralph Wiggum - traumatic brain injury leading to intellectual disability
- Rod Flanders - diabetes
- Selma Bouvier - anosmia
- Seymour Skinner - acid reflux
- Sideshow Mel - lactose intolerance
- Tripod Spuckler - polymelia (an extra leg)
- Waylon Smithers, Jr. - possible visual impairment, thyroid disease, lactose intolerance
- Waylon Smithers, Sr. - possible visual impairment
- Wendell Borton - nausea, diarrhea, vomiting, albinism
- Wheel Spuckler and Barrow Spuckler - conjoined twins
Psychiatric & neurological[]
- Abe Simpson II - dementia, PTSD
- Artie Ziff - narcissism, possible erotomania
- Bart Simpson - ADHD, PTSD, possible conduct disorder
- Carl Carlson - schizophrenia
- Charles Montgomery Burns - dementia
- Clancy Bouvier - PTSD
- Duffman - dyslexia
- Gary Chalmers - anxiety disorder, borderline personality disorder, intermittent explosive disorder, aerophobia
- Gil Gunderson - suicidal tendencies
- Gloria Prince - kleptomania
- Groundskeeper Willie - intermittent explosive disorder
- Homer Simpson - PTSD, kleptomania, suppression and repression
- Johnny Tightlips - possible anxiety disorder
- Kearney Zzyzwicz - dyslexia
- Krusty the Clown - formerly coulrophobia, bipolar disorder
- Legs - possible neurodiversity
- Lisa Simpson - PTSD, OCD, possible narcissism, formerly anorexia, depression, anxiety disorder
- Louie - neurodiversity
- Maggie Simpson - attachment disorder
- Marge Simpson - suppression and repression, formerly aerophobia, OCD
- Moe Szyslak - suicidal tendencies, homicidal tendencies, Bell’s Palsy
- Most Springfield residents - intellectual disability
- Ned Flanders - fanaticism, OCD, suppression and repression
- Nigel (Moho House) - anxiety
- Richard “Rich” Texan - OCD
- Robert Terwilliger - antisocial personality disorder, sociopathy, psychopathy
- Seymour Skinner - PTSD
- Shauna Chalmers - ODD, intermittent explosive disorder
- Snake Jailbird - kleptomania
- Stephen Hawking - motor neurone disease (ALS)
Addictions / Compulsions[]
- Amber Simpson - substance dependence
- Annika Van Houten - nicotine dependence
- Barney Gumble - alcohol dependence, caffeine dependence
- Bart Simpson - formerly alcohol dependence
- Bernice Hibbert - alcohol dependence
- Buck McCoy - alcohol dependence
- Bouvier family - nicotine dependence
- Carl Carlson - formerly substance dependence
- Charles Montgomery Burns - substance dependence
- Clancy Bouvier - formerly swearing disorder
- Donna - nicotine dependence
- Eddie Muntz - nicotine dependence
- Edna Krabappel - nicotine dependence
- Elizabeth Hoover - nicotine dependence
- Frankie the Squealer - squealing
- Gina Vendetti - nicotine dependence
- Ginger Flanders - nicotine dependence
- Groundskeeper Willie - alcohol dependence
- Hans Moleman - formerly alcohol dependence
- Hettie Mae Boggs - alcohol dependence, substance dependence
- Homer Simpson - alcohol dependence, eating disorder, nicotine dependence, formerly substance dependence, formerly swearing disorder
- Jessica Lovejoy - nicotine dependence
- Johnny Tightlips - nicotine dependence
- Julius Hibbert - substance dependence
- Kent Brockman - alcohol dependence
- Krusty the Clown - nicotine dependence, gambling disorder
- Legs - nicotine dependence, gambling disorder, alcohol dependence
- Lenny Leonard - formerly substance dependence
- Lionel Hutz - alcohol dependence
- Lisa Simpson - formerly nicotine dependence
- Louie - nicotine dependence, gambling disorder
- Marge Simpson - nagging disorder, formerly gambling disorder, formerly nicotine dependence
- Minnie Szyslak - substance dependence
- Mrs. Muntz - substance dependence
- Ned Flanders - speech disorder
- Nelson Muntz - nicotine dependence
- Otto Mann - substance dependence
- Rainier Wolfcastle - substance dependence
- Robert Terwilliger - recidivism
- Roger Meyers Jr. - nicotine dependence
- Shauna Chalmers - nicotine dependence
- Snake Jailbird - nicotine dependence
- Timothy Lovejoy Jr. - substance dependence