While Homer is eating at the many fast-food restaurants during his farewell tour, the song "Hungry Like the Wolf" by Duran Duran plays.
The name of the cigars Homer smokes is "Jerk-Ass Homer brand Cigars," a reference to Homer's characterization during the Mike Scully-produced episodes, in which Homer was childish, obnoxious, and had little to no remorse for others. The word "jerkass" originated on the season nine episode "The Joy of Sect," when Homer yelled, "Out of my way, jerkass!" while talking to the Blisstonians.
Ralph mentioned Elmo from Sesame Street.
One of the restaurants on Fast Food Boulevard is named Dead Lobster, a pun on the seafood chain Red Lobster.
Former Governor Vincent Aleppo is named after the State of Aleppo in Syria.
It is heavily implied in this episode that Moe Szyslak can't vote as he is a registered sex offender.
This is notably one of the few episodes where Homer's perspective on a concept actually proves to be correct, as he imagines quite correctly what a Think Tank is when Lisa suggests it. This fact is even noted in the episode when, shortly after imagining it, sees his family staring at Homer as if completely shocked, and Homer says "What? Not allowed to get one right?"
Juan Perón, former Argentine president, was mentioned in a chat that Lenny and Carl had in Moe's Tavern. This erroneous fact caused the episode be banned in most of Latin America (along with the reference that Peron's political dissidents "disappeared" and his wife, Eva, was Madonna—who played Eva Perón in the movie Evita), since they refer to Perón as a "dictator" while Mr. Perón is the only president in the country's history to be elected democratically by three periods. Confusion might be originated in the fact that Perón was ranked as General in the Argentine Army. The fact remains that he participated as minister in the coup that made him rise as a political figure.
In the episode, the political map shows shows that the U.P. of Michigan is white (neutral), while the lower part of Michigan is blue (Democrat). This is one of several episodes where the U.P. is identified on a map as a separate state.
After Springfield's State holds its primary, it is mentioned that 49 states still have to hold a primary. As always, the episode does not mention which state Springfield's State replaces. Also, according to the political map, there are (at least) 51 states if the U.P. is counted as a separate state.