Grandma Van Houten is Milhouse's paternal grandmother and Kirk's mother. Milhouse and his parents had to stay at her apartment while their house was sprayed for potato bugs. She was married to his Grandpa, but they got a divorce. She lives on 257th Street.
- Episode – "Bart Sells His Soul"
- Episode – "Raging Abe Simpson and His Grumbling Grandson in "The Curse of the Flying Hellfish"" (mentioned)
- Episode – "Milhouse of Sand and Fog" (picture)
- Episode – "The Yellow Badge of Cowardge" (picture)
- Episode – "Walking Big & Tall" (flashback)
- Episode – "The Kids Are All Fight" (picture)
- Comic book – Simpsons Comics 114
- Video game – The Simpsons: Tapped Out