The episode's title is modeled after the AC/DC song "Highway to Hell", which played during the closing credits of "Simpsons Bible Stories".
The Krusty Burger Munchie meals are modeled after the Jack in the Box's Munchie Meal Boxes, whose advertising campaign was accused of targeting the "stoner" market. However, many Jack in the Box locations operate where recreational marijuana is legal.
A few months after this episode aired, cannabis was federally decriminalized (yet still illegal in some states).
When Marge entered the restroom after becoming high, a close up of her blood-shot eyes revealed she has light blue eyes, yet in "Little Orphan Millie", Marge's eyes are revealed to be Hazel.