Apu, Skinner, and Moe were all volunteer firefighters in this episode. They would later also be volunteer firefighters in "Crook and Ladder." And Apu, Moe, and Ned Flanders were also volunteer firefighters in Brother's Little Helper. Luann van Houten was shown as being a member of the Volunteer Fire Department in this episode.
Some fans of The Simpsons have held parties on June 5th and calling it "The Feast of Maximum Occupancy", in reference of Homer's excuse to get out of work by making up a holiday by looking at the safety warning at Moe's Tavern, which read "Maximum Occupancy, 65". The June 5th party date is a reference to the digits 6 and 5.
At the end of the episode, God mentions that Homer has to wait 6 months to know the meaning of life, because Homer will die. Homer later dies for a few seconds in "Homer's Triple Bypass". Ironically, that episode also has Homer dreaming about what is implied to be Hell and referring to it as a "wonderful dream."
Despite this, God soon tells Homer the meaning of life, but the closing credits start before the audience can hear it.
This is the first episode to be animated by Film Roman.
The date of the Playdude is July 1986.
When Homer skips church and watches TV at home, he watches The Three Stooges (obvious due to a Curly-like cry coming from the TV).
When Homer dances in his underwear, it is a parody of the dancing scene from Risky Business.
Playdude is a parody of Playboy.
At the end of the episode when Homer sets the family home on fire he is rescued by Ned Flanders, however it is a Sunday, therefore Ned should have been at church. Even very religious people will skip church sometimes. Also, most churches have more than one mass so Ned could have went earlier or later. Similarly, some sects of Christianity split the church into "wards", so as to avoid overcrowding by having everyone at church at once; Ned's "ward" may have attended earlier. It's also possible that Ned was late and was on his way there when he saw the fire.
God is the only character to have 5 fingers on each hand, but only has 4 on each hand (like most Simpsons characters) during the scene at the end of the episode.
When Marge says, "Kids, your father doesn't really mean that," Bart is in front of Homer, but immediately afterward, Bart is suddenly behind Homer. Then, when Marge asks, "Homer, are you actually giving up your faith?" Bart is in front of Homer again.