This is the second time that a character discovers having a blemish and upon telling it "Not on my day, you don't!" it instantly recedes/recovers (in this case, Homer being hit with a falling flower pot and receiving a bruised bump on his head). The first is when Marge discovered that she had a zit on her lip while preparing for her "third" remarriage (actually second, as Reverend Lovejoy's remarrying Marge and Homer didn't count as his ministering license had expired during that time) in the episode "Wedding for Disaster".
This is the second episode where a Simpson rides on a garbage barge. The first being Homer the Heretic.
This is the second episode that produced in the 16:9 HD format.
At the gas station toilet, the song Ralph sings is Wannabe by the Spice Girls (before getting interrupted by Principal Skinner).
In the Sitcom Parodies couch gag, the Simpsons find themselves as the main characters on famous shows. The shows they go from door to door were in order: The Honeymooners, The Dick Van Dyke Show, The Brady Bunch and Cheers.
Kelsey Grammer, the voice of Sideshow Bob, makes a cameo on Cheers as his character Dr. Frasier Crane (both on that show and the spin-off Frasier.
Footloose plays when the principals and the kids begin to dance at the end of the episode.
At the beginning of the school year, the Welcome Back banner announces that MISS CALDECOTT IS NOW MR. NEWBERY. These are names of longstanding awards given out for children's books.
Oddly, Homer had a flashback from Treehouse of Horror XIII. However, he could have been exaggerating about lots of Homers falling off the cliff.
Homer's premonition of the massive accident in his house (aside from Marge Simpson and Lindsay Naegle making out) is similar to the premonitions seen in the Final Destination franchise.
During this episode (at the beginning) Homer remembers most of the times he got injured.
Despite taking place in September, the calendar in Ms. Krabappel's reads April. However, due to Edna's lack of interest in her job this is common for her to neglect her calendar. This goof also occurs in "Lard of the Dance."
When Skinner and the kids watch that a thief steals the bus parts, Otto is on the disassembled bus. But in the next shot, he is among the kids.
When Maggie's toy cannon launches the knife, Mr. Burns doesn't have a scratch when the knife lands on him.
In Homer's unreality, Helen has two left feet. It's Homer's unreality. Considering how stupid he is, it's totally in-character for him to think that Helen has two left feet.