This is the first episode in the series that primarily focuses on Marge.
The original title of this episode was "Bjorn to Be Wild". This is because it called for Albert Brooks to voice Bjorn, a Swedish tennis instructor, but Matt Groening thought it would be better to make Brooks' character French. This then led to them nearly calling the episode "Jacques to Be Wild". Interestingly, and nineteen seasons later, in "Coming to Homerica", the name was recycled to name a bunky, athletic-alike Ogdenviliian man of Norwegian heritage (another Scandinavian country), who seems to fall in love not with Marge, but with Selma instead.
The moon is seen to have three craters on it, much like a bowling ball when Jacques is dropping Marge off.
This is the second and last episode to not play the theme but instead fades from the street in the intro to a shot of the Simpson house as the first six notes play on horns instead of xylophone dings, the seventh note draws out as the camera zooms onto the house, a quick drum roll plays to repeat the seventh note, and the episode begins from there. This first happened in "Bart the General".
When the street in the intro fades to the Simpson house in this episode, the shot is different than the shot used in "Bart the General". In "Bart the General", the Simpson house shot was the infamous three-quarter front view, while in this episode (Life on the Fast Lane), the Simpson house shot is a front view instead.
Marge turns 34 years old in this episode (She used to be 33 years old for the first eight episodes of Season 1 and of the whole show), and has been 34 since this episode.
This is the first episode in which Homer almost loses Marge.
If Marge is 34, this would mean she gave birth to Bart, now 10, when she was 24. This is inconsistent with most flashbacks to Homer and Marge's earlier lives.
Jacque says "four onion rings" without his French accent which could indicate that he is not French at all and his accent was fake.
When Marge is seen twice putting on bowling shoes, she is putting them on her bare feet. In real life, you need to wear socks with bowling shoes in order to prevent the spread of foot fungus.
In addition to this, Marge is seen wearing socks in bowling shoes in "The Great Wife Hope" which makes this point even more valid.
The filling of Homer's sandwich changes from green to purple.