The Virtual Doctor website says that it's from the creators of Dragon Quest and SimSandwich. Dragon Quest is a series of RPGs released by Square Enix (originally released as Dragon Warrior in the US). SimSandwich is a reference to the Sim series of games by Maxis (later acquired by Electronic Arts, who made The Simpsons Game), the most famous of which are SimCity and The Sims. The Dragon Quest name is most likely coincidental and NOT meant as a reference to the real life game series of the same name.
The "You Got Leprosy" line said by the Virtual Doctor is modeled after AOL's "You Got Mail" greeting. Elwood Edwards recorded numerous greetings himself in 1989, including "You Got Mail," which were then incorporated into AOL in October 1989
This medication is used to treat various cancers (e.g., leukemia, melanoma, AIDS-related Kaposi's sarcoma). It is also used to treat virus infections (e.g., chronic hepatitis B and chronic hepatitis C). This medication is the same as a protein that your body naturally produces (interferon)
This is the second episode to be banned in Japan, the first being "Thirty Minutes Over Tokyo". The reason dealt with the Leprosy subplot and the segregation element, as segregation laws were still deemed a sensitive matter in Japan.
Although the clock falls on Marge's left leg, it only breaks her right leg.
Even if Marge's right leg grew hairs due to it being a week, it's unlikely that her leg one didn't get hairy too.