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Louis Howland "Lou" Simpson (1882-1977) was the youngest son of Howland Simpson I and Gabby Crouse. He married Zorina Ovadia and the couple had three children named Echardt Simpson, Bob Simpson and Twyla Simpson. He is also the maternal grandfather of Fernice Schedeen and Ingrid Schedeen. He is the paternal grandfather of Vern, Verna, Eckhardt and Lotus He is Orville's paternal uncle, Abe's paternal granduncle, Homer's paternal great-granduncle, and Bart, Lisa, and Maggie's paternal great-great-granduncle.

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