Mark Zuckerberg is the co-founder of Facebook.
Lisa and Nelson see him at an entrepreneur expo. He is seen using Facebook and when he meets Lisa and Nelson, he changes his status to "happy to meet new friends". He reveals that he dropped out of Harvard and still became rich and successful. He then had a play fight with him on Richard Branson's shoulders and Nelson on Bill Gates' shoulders.
He was later seen at a rollerskating ring and was accidentally knocked over by Lisa and Nelson. He changed his Facebook status to "is in intense pain" to which Nelson replied "Haw Haw!" and Lisa replied "Sorry".
- Mark appears to be friends with Moe Szyslak, Dr. Hibbert and Kent Brockman on Facebook. He has also interacted with Cookie Kwan, Hank Scorpio, Lucius Sweet, Hollis Hurlbut and Tattoo Annie.