Michael is the son of infamous mafia boss Fat Tony, but he does not wish to follow in his father's footsteps and go into the family business of "Waste management." He has a passion for cooking and is a great chef. Due to his father's reputation, he was fearfully alienated by his classmates and school staff, except for Lisa Simpson, who befriends him.
His mother died when he was younger and has no siblings. Fat Tony was once put in a hospital by rival gangs (The Calebresis) and Michael was offered to take over the mafia for a while. He didn't want to, so Homer and Bart Simpson took over the mafia instead, although later he apparently willingly poisoned the mafia that had attacked his father and seemingly ends his friendship with Lisa, telling her to never ask him about his business.
- Murder: In "The Mook, the Chef, the Wife and Her Homer," he made food for the Calebresi mobsters which he laced with poison, leading to the men dying on the scene.
In the comics, Michael has his own junior mafia, consisting Louie's son, Louie Jr., and Legs' son, Calves. He inducts Bart into it. They try to steal some stuff from their school before they're stopped by Lisa.
- Michael is an obvious homage, in name, appearance and behavior, to Michael Corleone from The Godfather Trilogy.
- His name may also be a reference to actor James Gandolfini, who played Tony Soprano in The Sopranos, and his own son, Michael Gandolfini.
- Marge Simpson and/or Fat Tony (Then later, Fit-Fat Tony) sometimes drives him to and/or from school.
Season 33 (TBA)
|Don Vittorio DiMaggio | Fit Fat Tony | Louie | Legs | Joey | Johnny Tightlips | Michael D'Amico | Frankie the Squealer | Jimmy the Snitch | Joey the Arsonist|
|Former Mafia Members|
|Fat Tony (deceased) | Bart Simpson | Homer Simpson | Nicky Bluepants Altosaxophony|
|Joe Quimby | Snake Jailbird | Krusty the Clown | Luigi Risotto | Marge Simpson|
|Ms. Albright | Alice Glick | June Bellamy | Belle | Billy (actor) | Booberella | Colin | Cosine | Crazy Cat Lady | Michael D'Amico | David (Treehouse of Horror XVI) | Devan Woosterfield | Dia-Betty | Mia Farrow | Ginger Flanders | Mrs. Glick | Adil Hoxha | Bernice Hibbert | Cookie Kwan | Lester | Audrey McConnell | Medicine Woman | Mrs. Muntz | Lindsey Naegle | Manjula Nahasapeemapetilon | Opal | Poor Violet | Lois Pennycandy | Pepi | Phillips | Brunella Pommelhorst | Ronaldo (Blame It on Lisa) | Dr. Simpson | Agnes Skinner | Brandine Spuckler | Jitney Spuckler | Whitney Spuckler | Spud | Dolph Starbeam | Clara Stetson | Gino Terwilliger | Dame Judith Underdunk | Veronica | Vicki Valentine | Plopper | Princess Diana|