Nana Sophie Mussolini is the mother of Luann Van Houten and Milhouse's maternal grandmother. She is from Italy and hates the English language, because an American WWII soldier left her pregnant with Milhouse's uncle Bastardo. She used to whip Milhouse whenever he spoke English instead of Italian.
- Episode – "The Last of the Red Hat Mamas" (flashback)
- Episode – "Treehouse of Horror XXIX"
- Video game – The Simpsons: Tapped Out
- The grandmother in "Bart Sells His Soul" and the one in "The Last of the Red Hat Mamas" must be two different characters, since one of them lives in Tuscany, while the other is seen living in Springfield. Additionally, Nana Sophie doesn't seem to speak English, while Grandma Van Houten does.
- In the Italian dub, she lives in Tuscany but she is from Sicily. In fact, she whips Milhouse because he speaks in Italian rather than Sicilian dialect.
- Sophie shares her surname with Italian dictator Benito Mussolini.