Nuclear Waste is a form of waste created by nuclear power. The Springfield Nuclear Power Plant creates a lot of nuclear waste which is dumped into rivers and mutates fish like Blinky. In the children's video Nuclear Energy: Our Misunderstood Friend in the episode Homer's Odyssey, three Uranium 235 Rods create nuclear power and three small monsters that represent nuclear waste. Smilin' Joe Fission then sweeps them under a carpet, where no one will find them for a million years. One escapes and he kicks it away.
Before his short-lived fame of getting a perfect 300 at the Bowling Alley, Mr. Burns forced Homer to eat several barrels of nuclear waste as punishment for being 26 hours late for work.