The closing caption that thanked viewers for 450 episodes originally read: "The Best is Yet to Come" at the end. The second time this episode aired changed the last caption to: "Now stay tuned for three Seth MacFarlane cartoons" (referring to Family Guy, The Cleveland Show, and American Dad!) and the syndicated version changed it to: "Think of all the things you could be doing instead of wasting your time with this show."
Guest star Eartha Kitt is best known for her role as Catwoman, in the 60's Batman series (as Julie Newmar's second replacement, followed by Lee Meriweather in the series' movie). Conversely, fellow guest star Anne Hathaway (Princess Penelope) played Catwoman in the Batman movie The Dark Knight Rises.
The last time someone called themselves a "star wars" was in "Bart Has Two Mommies".
This is the first episode where the Simpsons have an HDTV.
Sophie is, quite surprisingly, absent at her father's wedding. It is possible that her mother kept her from attending or she was not informed of its occurrence.
This episode was promoted as the 450th episode, when it is actually the 451st.
Anne Hathaway also played a princess in the Disney film, The Princess Diaries.
When Mr. Burns is offering Homer, Carl and Lenny the donuts, they are colored pink, brown and white. When they eat them, all of them are pink.