When Cletus' dog knocks one of the birds to the ground, a squirrel reacts to it saying "Black Hawk down!", a reference to the Black Hawk utility helicopter and the movie Black Hawk Down.
The song "Together Forever" by Rick Astley plays during the small montage showing Patty and Selma smoking during different phases of their lives (and after their deaths) at the end of the episode.
When removing the last "s" it becomes "Puffles", a reference to Club Penguin.
This is the second episode where Patty and Selma quit smoking and at least one of them relapses. The first was "Opposites A-Frack".
It is revealed that Clancy Bouvier died of lung cancer. In "Jazzy and the Pussycats", Homer makes a reference to Clancy Bouvier being dead by saying "I know I will use that white noise machine I got you, when your father died." while he was in bed with Marge.
When Marge tells Homer that Patty will be sleeping on the couch, Homer breaks the fourth wall by saying "But that's where we do our couch gags!" and we then cut to the couch gag seen in the episode.
On Selma's past list of lonely men, Sideshow Bob was there, which was a reference to "Black Widower".
This episode marks the return of Spider-Pig.
Maggie's plan's subtitles also breaks the fourth wall: After securing the perimeter, the ground troops will advance and reinforce flanks, as the aerial units will soften their defenses. Then we shall advance in a pincer moment to infiltrate the compound and liberate our friend. If you've read all of this, congratulations, you're a genius!