Realizing that he's ugly after his face gets censored on the new Duff calendar, Moe gets plastic surgery and gets back at everyone who thought he was too ugly — which lands him a role on Springfield's most popular soap opera, It Never Ends. Meanwhile, Bart and Lisa chase after Maggie's runaway pink elephant balloon.
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One morning the fire alarm goes off, everyone grabs something of theirs and rushes to the car, unfortunately Homer set off the fire alarm to get them to the beer convention. As it turns out Moe is competing in a bartender competition. Unfortunately Moe does have some tight competition but he comes through in the end. After winning the bartending contest, Moe is shunned by the Duff brewing company when his picture on their calendar has stickers over his face. After peeling away all the stickers, Moe is shocked to see how ugly he is (especially when Carl compares Moe's ugliness to Lenny's stupidity, Barney's drunkenness and Homer's laziness, baldness and weight). Moe gets a facelift, becoming very handsome, and sets out to do all the things he never could, including almost getting a date from a girl he liked in high school, and being surrounded by beautiful women (and Selma). He then tries out for a role on Soap Opera It Never Ends, who had turned him down years ago for being 'ugly-ugly'. Now with his leading man looks, he is offered the role of leading man Dr. Tad Winslow. The new episodes of Moe premiere and while Lisa is unsure if she'll accept Mo as Dr. Winslow, Marge doesn't mind as long as the show retains it's regular points. Moe's popularity is so incredible that ladies are soon hanging out in the bar which surprises the bar flies.
After misinterpreting a plot line, Moe thinks his character is being killed off. He sneaks Homer on to the set to make a guest appearance as an angel from the future, and gives away a year of the soap's story lines. The irate producer comes in and explains that Tad Winslow was only going to be killed off in a dream sequence. The producers go to fire Moe, but Moe quits, citing that he can get on any soap opera he wants because of his handsome face. Unfortunately, as he leaves, the set falls on top of him, turning his once-handsome face back to his original ugly mug.
Moe then returns to his old job at Moe's, which almost was going to be sold and turned into a Hooters, much to Homer's shock. Moe then wonders to himself why the set falling on his head turned his handsome face back to his old face instead of making a third, uglier face, but the episode gets cut off before he can continue the pondering.