Queen Elizabeth had intended to confer knighthood to Krusty the Clown, although Krusty was forced to leave at the last second before being formally knighted due to a riot breaking out at Kamp Krusty. She eventually knighted Elton John in 1998, with his claiming later on that she "paddled him silly" before the ceremony.
When The Simpsons went to London on their holidays, Homer hit her carriage with the Mini Cooper he rented. Because of this, as well as Homer's assumption that she was an imposter due to the initials on her luggage saying "H.R.H.", which in his mind meant Henrietta R. Hippo instead of "Her Royal Highness", she sentenced Homer to be imprisoned in the Tower of London and later executed by decapitating him and later placing his head on a spike. After Homer's backfired escape through a secret passage, she later pardons Homer and allows him to leave England after he apologises, although under the condition that the Simpsons family take Madonna with them when they leave.
- In "The Regina Monologues" her luggage carried the inscription H.R.H which means Her Royal Highness, which is used for Princes and Princesses, but since she is the Queen, her luggage inscription should have read H.M. as in Her Majesty, because that is her official style, but prior to ascending to the British Throne, she did carry the style Her Royal Highness Princess Elizabeth, Duchess of Edinburgh.
- She was born on April 21st, 1926.
- Before The Simpsons premiered on television, she became queen of the United Kingdom on February 6th, 1952 at the age of 26 and was crowned a year later on June 2nd, 1953 at the age of 27.
- Episode – "Kamp Krusty"
- Episode – "Behind the Laughter"
- Episode – "I'm with Cupid" (mentioned)
- Episode – "The Regina Monologues"
- Episode – "The Mansion Family" (mentioned)
- Episode – "To Surveil With Love"
- Episode – "A Midsummer's Nice Dream"
- Episode – "Married to the Blob" (Shown on the cover of The Death of Radioactive Man)
- Episode – "Haw-Haw Land"
- Episode – "The Princess Guide" (mentioned)
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