Senator Mendoza is McBain's nemesis in several films.
Mendoza was a respected senator in the eyes of the public; however, behind the scenes, he secretly ran an international drug-cartel. McBain stumbled upon evidence that he was running the cartel, and thus attempted to bring Mendoza to justice. Mendoza also arranged for an assassination attempt on McBain at a diner via a planted "waiter," but Skowie, McBain's police partner and best friend, ended up taking the bullet. Mendoza manages to capture McBain with a rigged salmon puff but leaves it to his men to finish him off. At a meeting with his board of directors, Mendoza is told that McBain has met "an unfortunate accident". However, McBain suddenly appears and kills the rest of the board before hurling Mendoza (who was attempting to sneak attack him with a pistol) out the window onto a gas truck that explodes on impact, killing Mendoza.
- Episode – "The Way We Was" (Mentioned)
- Episode – "Oh Brother, Where Art Thou?"
- Episode – "The War of the Simpsons" (Mentioned)
- Episode – "Saturdays of Thunder" (Mentioned)
- Episode – "Last Exit to Springfield"