The Shelbyville Nonuplets Minivan is a car in the mission "Eight Is Too Much" from the game The Simpsons: Hit & Run. This mission is where Apu has to hit the back of it in order to collect the diapers to complete the mission. The van is an orangish brown color and has the nonuplets at the back of it visible through the windows.
Strangely, the Nonuplets Minivan is by far the hardest vehicle to destroy in the game, as it is coded to have 99 Hit Points. For context: the super frail Speed Rocket has 0.3 HP, while the extremely sturdy Armored Truck only has 15 HP. The Minivan's excessively high HP makes the it basically impossible to destroy in the mission it appears in, and makes the Minivan take over 20 minutes of non-stop crashing to destroy if driven by the player using the "Unlock All Cars" cheat.