Near the end of the West Coast version of the episode, Homer states that, "To prove that we're live, the Texas Rangers beat the Toronto Blue Jays on a technical knock out." Hours before the episode aired, Rangers second baseman, Rougned Odor punched Blue Jays right fielder Jose Bautista in the face during the eighth inning of the game.
When Homer's "mind explodes with premises", the woman siting on the chair in the "Philosophy: Objectivism" section is Ayn Rand, who was the creator of the philosophy Objectivism.
Bart knocks down the Fox Studios Secret Bunker walls, revealing it's on The Simpsons' living room.
Ralph's treehouse appeared on the September issue of the Treehouse Beautiful magazine. This indicates that the beginning of the episode takes place in September. This also indicates that Ralph's birthday is in, or at least close to September.
The last time a Simpson was talking to the audience at the end of the episode occured in Bart the General.
At the Springfield Fringe Festival, Lisa's tie changes from gray to blue, and later back to gray.
When Bart has a nail in his head, he reassures Marge that it is all mostly hair. However, it would be impossible for the nail to be sticking that far out of Bart's hair without falling. Also it is very unlikely that he would know it's still his hair just because most of his head is hair, because in The Blue and the Gray he didn't know where is his hair starting.
In some Latin American airings, the Live segment was aired without any sound. Later an apology video was posted on the YouTube channel Animation Domination.