This episode marks the first of several Simpsons clip shows.
The clip of "Homer falling down the cliff" has some new animation that wasn't in "Bart the Daredevil". When Homer falls down the second time, we actually see it rather than just hearing it in the actual episode. If you look closely, you can see that the animation looks much newer.
Writers Al Jean, Mike Reiss, Jay Kogen, Wallace Wolodarsky, John Swartzwelder, Jeff Martin, George Meyer and Nell Scovell are acknowledged during the end credits of the episode.
Around the time this episode aired, Al Jean and Mike Reiss wrote the pilot for their show, The Critic.
A scene was cut but re-made into the DVD season pack where Professor Frink visits Homer's hospital room with a plan to create a shrinking submarine and plans to travel inside the coma-sudden Homer by entering his rectum.
Barney is seen throwing a water fountain through a window. This is a reference to the movie One Flew Over the Cuckoo's Nest.
Since Bart's birthday is on April Fool's Day, the family would've remember to celebrate it instead of pulling off pranks. It is possible that Bart was congratulated off-screen and that his birthday thus wasn't episoded.
This part's debatable, but during one clip, the Simpsons actually remembered themselves being abducted by aliens at one point. It is unknown if the segment from Treehouse of Horror, Hungry are the Damned, is considered within continuity or not.
One repeated clip is the dream sequence from Lisa's Pony, occurring in that episode when Homer falls asleep at the wheel of his car. However, the music from the original episode - an instrumental version of Golden Slumbers by the Beatles - is replaced in the clip show with an unidentified piece of music, possibly intended to sound similar.
Print television ads promoted this episode as the series' finale. It was later known as an April Fools' Day joke.
When the veterinarian offers to spay Homer, this is incorrect since spay is the removal of the ovaries and/or uterus in a female animal. The correct medical term should have been neuter.
When Homer goes to get another beer (that had been shaken), he opens it and the house explodes. During an overhead shot of the house, you can see that one of the second floor windows has been moved further.
Bart's April Fool's Day prank on Homer and its results was tested in 2018 to see if it had any basis in reality, and it was discovered that a soda shaken by a paint mixer actually has less spray distance than a hand shaken can, with it being explained that it was actually the failure to return to equilibrium due to changes in phase states that causes it to explode and not simply shaking it.
When Homer takes a beer from the fridge (before the one that explodes due to Bart's prank) his head is not seen and appears to be hidden behind the freezer's door.
Call-Backs to Episodes (In order of appearance in the episode)