Hypnotoad and the Horrible Gelatenous Blob from Futurama make a cameo.
This is the first episode where Bart throws spitballs at Lisa to get her attention.
At the end of the episode, Homer (in the future) is watching TV with his counterpart from the Musicville couch gag which started this episode.
This is an episode where it was edited in the name for the future episode The Kids Are All Fight.
Lisa quotes Mr. Burns once again with his phrase "Excellent" after watching a video of Isabel on training wheels (Lisa previously did this in "Little Big Mom" when she tricked Homer and Bart into thinking they had leprosy).
The Musicville couch gag could be referring the Music Land animated short. Some similarities are: similarity in names (Music Land and Musicville), both having a main character/characters as brass instruments, Music Land is a Silly Symphonies short and in the couch gag it says that Musicville is a Silly Simpsony, both have different musical lands with Music Land having the Land of Symphony and the Isle of Jazz and the Land of Springfield have Musicville and Metalville, both worlds bridge connections with the Bridge of Harmony in Music Land and bridges seen on the map of the Land of Springfield in Musicville and a imprisonment involving Jazz with the Prince of the Isle of Jazz being imprisoned by the Queen of the Land of Symphony Mr Burns of Music Land imprisoning the people at the jazz festival
When Homer is in the attic talk (between Marge and Lisa) scene he says two big 80's two quotes. The first being "Where's the beef" is a slogan for the fast food chain Wendy's introduced in 1984 and the second is "Tear down this wall" a quote from a Ronald Reagan speech to USSR president Mikhail Gorbachev about the Berlin Wall said on 12 June 1987
This episode shows that Waylon Smithers, Jr. is lactose-intolerant.
Lisa's relationship with Nelson is mentioned in this episode.
Lisa's tablet says that Harry Nolsson "composed" the song "One", and died of a heart attack on Valentine's Day. In reality, Nolsson merely wrote the lyrics to the song. And while he really did have a heart attack on February 14, 1993, he survived it, only to suffer another fatal heart attack on January 15, 1994.
Marge was said to have voted for Reagan, but she would have to be at least 48 for this to be true, or at least 52 to have voted for him in 1980, however Marge is only 39.
Also, it has previously been mentioned that Marge voted for Jimmy Carter, although she could have voted Carter in 1980 and Reagan in 1984.