The Three Strikes Law that served as the reason for Snake's execution was later used in The Simpsons: Hit and Run for the mission "Slithery Sleuthing" in Level 3. Unlike in this episode, Snake did not end up executed, with it instead being implied in Level 5 that Snake was instead sentenced for an unknown duration of community service as a result.
Originally, the televised execution of Snake was supposed to be hosted by Troy McClure (with McClure voiced by Phil Hartman). When news hit that Hartman was murdered by his wife, Brynn, the original scene was replaced with one where Ed MacMahon (who voiced himself) is the host.
This is one of the few episodes where someone else tries to kill Bart instead of Sideshow Bob (in this case Snake, Itchy and Scratchy)
Moe's the only one of Homer/Snake's murder victims (or in the case of Bart, near-victim) who doesn't deduce that Snake is controlling Homer's actions from beyond the grave (presumably because, unlike with Apu or Bart [with his explicitly blaming him for being sent to the Electric Chair, and referring to him as "snitchy", respectively], he does not make any comments that point to his true identity beforehand).
During the Jerry Springer portion of "Starship Poopers", Kang briefly lifts the chairs with his tentacles and attempts to use them as weapons against Homer. In actual episodes of Jerry Springer, the chairs were deliberately made oversized specifically to deter the guests from using the chairs as weapons during the show's infamous on-stage fights.
In the intro, the garage door is purple-pink instead of its usual peach-tan color.
When Marge and Maggie honk their horn to tell Homer to move out the way Maggie body is left out in the scene.
When Barney calls dibs on Snake's liver, he is missing the hair from his chest.
At the beginning of the same shot, the lenses of Ms. Hoover's glasses are colored yellow even in the area where they overlap the background, not her face.
When Homer leaves the bedroom in the middle of the night, his hair is darker than usual, presumably because of the lighting. But a few moments earlier his hair was colored its usual color despite the lighting being the same.
As Lou points to the dead Apu, his tie turns blue for a frame.
When Homer enters Moe's to kill Moe, Moe's chest lacks chest hair initially but then the chest hair appears in the next shot.
In the Jerry Springer scene where Homer attacks Kang while swearing at him, Maggie is briefly seen without eyes.
In another shot in the sequence, Marge briefly lacks eyelashes.