The 'collectibles' in the Collectors lair preserved in Mylar pouches are Spock (Leonard Nimoy) Gilligan(Bob Denver) M3-B9 G.U.N.T.E.R. (Lost in Space) Seven of Nine (Jeri Ryan) Doctor Who (Tom Baker 1974-81) Matt Groening (Don't Know Just some guy I guess lol) Xena (Lucy Lawless) and Yasmine Bleeth (Baywatch as Caroline Holden).
"Life's a glitch, then you die" is a reference to the catchphrase "Life's a bitch, then you die." and the Year 2000 problem although it aired two months before it happened, because it was a prediction.
"Desperately Xeeking Xena" coined the term "A wizard did it".
Moe's phone call was a reference to the movie Scream referring to having a poor excuse for a plot hole.
Homer tells the guard of the rocket that he is the piano genius from the movie Shine and that his name is Shiney McShine (the name he should have used is David Helfgott).
The band playing at New Year's Rockin' Eve is actually Ratt according to the drumset, though the band members thought they were either Quiet Riot, Poison or Whitesnake.
The Robotic Dick Clark is likely a reference to the fact that he seemingly didn't age after the age of 35 he looked pretty much the same at 80 as he did at 35.
Lisa being crushed by the bleacher with only her feet being shown is a reference to The Wizard of Oz when Dorothy's house crushes the wicked witch of the east.
In the third segment, Ned is wearing "Beatle Boots", which references that he was a fan of the Beatles before "The Bart of War".
The Lineup for the Exodus Rocket includes a Doctor, a nurse Bill Gates, Ron Howard, Former President Jimmy Carter, Stephen Hawking, Not Sure of Name, Paul McCartney, Not Sure of Name, Michael Jordan, Stephen Jay Gould, Michelle Kwan, Mark McGwire and Professor Frink then the Simpsons.
The Rocket beside Homer and Bart's is painted in the colors and design of the Flag of France
This is one of two episodes of this season where the Simpsons accidentally run over a character, getting caught, and the victim turning out to be still alive. The other one being "Kill the Alligator and Run".
This is the ninth Treehouse of Horror to have the cast's names changed due to Halloween (e.g. Bat Groening). The first eight were from Treehouse of Horror episodes II-IX.
This is the first of two Treehouse of Horror episodes to feature the segment writer's name at the beginning of each segment, with Treehouse of Horror XI being the other.
Some of the names The Collector wishes for Lucy to name him on their wedding night are: Obi-wan, Iron Man, Mr. Mxyzptlk and Big Papa Smurf.
According to the DVD commentary for this episode, Grampa was originally supposed to be the one run over by The Simpsons.
When Homer pokes the supposedly dead Flanders, he pokes him through the lenses of his spectacles.
Rod and Todd are not seen at Ned's funeral.
If Lisa was excepted to escape from Earth and go to Mars, why didn't she get a letter? They could have left the house in such a hurry they didn't check the mailbox.
When the Simpsons were inspecting their roadkill you can see Flanders' sleeves intact. In the flashback story of Flanders when he finally caught up with the Simpsons after their car broke down, you can see that Flanders's sweater sleeves are ripped due to his lycanthropic metamorphosis.
Stretch Dude was able to punch through the collector's base wall, but only Clobber Girl has super strength.
During the scene where Nelson is shut into the Xerox during the 1999 glitch, he is shown still wearing pants when showing him inside the Xerox machine, despite obviously using it to photocopy images of his own butt and thus having removed his pants earlier.