Not much is known about Tyrone. Due to his personality, it is more than possible that he grew up depressed and bitterly. It can be implied by his appearance, that he is Abraham Simpson's second oldest brother, after Great-Uncle Hubert.
Marge tells Bart and Lisa they are going to Dayton Ohio for their great uncle Tyrone's birthday. Lisa says when they were singing happy birthday to him last year he said "Why won't I die?". The kids decide not to go and stay home with Grandpa. Homer and Marge get on a different flight at the airport and don't go to see Tyrone.
It is unknown if he survived the tornado that tore through Dayton, but it is possible, seeing as it majorly destroyed the hotel where Marge and Homer were supposed to be staying. If so, it is unknown what happened to him after.
- He is implied to be the second oldest of Abe's brothers.
- This is evidenced by the fact that he says "Why won't I die", implying he is older than most people of an average lifespan.