Wendell is an albino boy who is a classmate of Bart Simpson in Mrs. Krabappel'sfourth grade class. He is often seen playing with classmates such as Richard and Lewis, and is also good friends with Martin Prince, who helped him with his election as class president against Bart. He is considered one of the nerds of the school along with Martin, Database and several others, making him a constant and easy target of Nelson and other bullies; however, he might also have some run-ins with the school rules, as he was seen in detention. Wendell was also one of the children who become stranded on the island with his fellow Model UN Club colleagues. His skin color sometimes changes to yellow in the background, such as in "Little Girl in the Big Ten", in which he is punched in the stomach by Kearney for lunch money. When the Simpson family get a new trampoline, he's among the kids invited to their place to jump on it, but the trampoline turns out to be hazardous and several kids end up getting hurt, including Wendell. At one point, he falls and exclaims "My arm!"
Wendell is known to have a dizzy feeling once in a while, such as when he threw up on a bus ride after Bart patted him on the back.  Another time, it's implied that Wendell vomited in the school's hallway, for which he apologized to Groundskeeper Willie, who's seen mopping up the mess left on the floor and behind. 
He got this rare disease after catching terminal cancer while listening to the "Final Cut" by Pink Floyd.
The contents of this article or section are considered to be non-canon and therefore may not have actually happened/existed.
In the Treehouse of Horror V segment "Nightmare Cafeteria", Wendell is among one of the last children not sent to their death along with Ralph and Lisa. However, Edna sends him to the principal's office when his pencil slips off his desk, sealing his fate.
In the Treehouse of Horror XXVI segment “WANTED: Dead Then Alive!”, Bart swings Wendell around 14 times on a roundabout, in a gambling game. However, the latter pukes on 14, thus meaning Bart keeps all the money.
In "Barthood", he can seen at Milhouse's graduation party at age eighteen.
Throughout the series, he has been voiced by Jo Ann Harris, Pamela Hayden, Nancy Cartwright and Russi Taylor. This is because of the fact that he rarely speaks and therefore does not have a specific voice actor. His most recent speaking appearance was in THOH 26 where he said he held his puke in on his 14th spin of the merry-go-round. Cartwright used his voice, since he sounded very similar to Todd Flanders.
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Episodes where he had a speaking role are in bold.